ISTREE - Informational Spectrum-based Phylogenetic Analysis
New approach in phylogenetic analysis allows at first time the assessment of functional viral evolution.
The Informational spectrum method (ISM) is based on the assumption that the protein-protein interaction encompasses two basic steps:
All of standard evolutionary models are based on the multiple sequence alignment (MSA). The main weakness of phylogenetic analyses based on MSA, is that sequence similarity does not necessarily imply similarity in functions. For example, two protein sequences that differ by a single mutation that is lethal for the biological function will nevertheless phylogenetically group together, whereas two proteins that differ in several mutations that do not affect biological functions will be phylogenetically separated.
In order to overcome this obstacle and to improve functional sequence analysis, we use a new distance measure based on the IS method. The ISM distance is sensitive to the position of mutation and the type of the substituted residue, in opposition to standard distances. ISM approach for generating phylogenetic trees and phylogenetic analysis (ISTREE) is not based on MSAs.
For more information of ISTREE, mathematical background, definition, properties of ISM distance and applications, please see:
You are welcome to use our free web service ISTREE for building the informational spectrum-based phylogenetic tree. Just input the protein sequences in FASTA format and submit data.
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